In trials
When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn’t working. So they began to just focus on one other, the Crohn’s, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.
I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.
Hope can be a dangerous thing. Hope can drive a man insane, as Red said.
T1 diabetes here. A cure is just 5 years away…
They told me, when I was diagnosed in 1992.
It always 5 years if properly funded. It’s never properly funded so always 5 years.
They are testing an artificial pancreas currently. The cost is the issue as always.
We can genetically engineer bacteria to mimic the missing pancreatic cells, and it’s not too different to the way most insulin is produced as all that’s new is the system to stop producing insulin when blood sugars are already low enough. However, if you put them in a person, the immune system attacks the bacteria, so they need isolating. To do that, we need a membrane that lets sugar in and insulin out, but doesn’t let antigens or live bacteria out, and doesn’t let immune cells in. Even if the bacteria are held in place, if immune cells can get in, it’s no better than a pancreatic transplant as you’ll still need immunosuppressants, and they’re generally worse than dealing with type one manually. Development of the membrane keeps hitting unexpected hurdles, so artifical pancreases are still unable to start trials, and then they might take a decade.
There are other approaches, e.g. using electronics to control photosensitive insulin producing bacteria, but they don’t have any advantages (the membrane still has to let sugar in so the bacteria can eat) and have more things that can go wrong.
In theory, and this is another couple of major advancements of this tech away, if you can teach the body to stop attacking specific cells you can do a transplant without rejection. Teach the body to not attack the new pancreas, then stick it in there.
This should be possible with this tech, though it would require a mature and advanced process compared to what we have now. Genetic chimeras can exist without the immune system going crazy, presumably because it recognizes all those parts as “part of the body”. If it can be taught to recognize other implanted material as acceptable that opens up a huge range of options. Even a lifetime of immune system training therapy is better than a lifetime of immunosuppressants.
Ultimately what they need to do is decipher stem cell development and fetal development and use the patient’s own cells to replace the lost islet cells.
If you don’t have a solution to the autoimmune aspect, then a stem-cell-based treatment is no better than one with engineered bacteria or someone else’s cells. The originals are gone because the body mistakenly thought they were foreign. A treatment like the article discusses might make stem cells more viable than the alternatives, though, as they’d be less foreign, so need less immune system alteration.
Commercially viable fusion is always 20 yrs away so keep your chin up
Well damn, I got MS too but caught it fairly early. I’m hoping for a major breakthrough before it gets really bad.
I came for the Orange reference, but was not disappointed by Red.
So, if I understand this right, a more accurate title would be “Research into vaccines against autoimmune diseases continues, new data indicate that a change of focus might be needed”
have Crohn’s. fingers crossed 🤞🏽
Website I’ve never heard of: check
Wild claims that seem too good to be true: check
Little to no proof about said claims: check
Don’t get me wrong, this would be fantastic if it’s true. But I’m sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.
like the good ol r/science
this place is going doooown
I see it in google news all the time. spammy but I don’t see their ads. they gave references near the end.
Every science article is just a comment section disapproving the article. That’s why I stay away from these science communities, it’s all clickbait and lies
At the same time, commenters don’t necessarily know what the fuck they’re talking about either.
Yeah Reddit always had that problem, I think it’s here too - top rated comment is someone saying it won’t work and the article is wrong, everyone just accepts it without question.
I still see people using battery breakthrough stories as an example of stuff that never comes too market despite most of them being in the very phone the person is using.
I genuinely think a lot of them are just people who hate science and engineering so don’t want people to be interested in it
I genuinely think a lot of them are just people who hate science and engineering so don’t want people to be interested in it
So strange for those people to hang out in science communities in that case, to me.
a cat group I started the same time as this has 5k more subs and no whining. it is just cat pics. there are a lot of fake science sites to avoid but they all have bills to pay. they expect it to be like reddit junk and all. been to reddit through search results and sometimes found useful threads. mostly not.
Yeah, I think they come from the front page, I don’t think you see it as much on more obscure articles.
Looks at that… The one thing good about reddit was the /r/science sub, it was always full of moderator deleted comments that were off topic, factually incorrect, etc. posted articles actually were scientific reports and not clickbait crap lik this
Wait. I read above that this article is good. No?
deleted by creator
What’s bad is that it’s a good article. It covers things very well
okay then
If we assume for a moment that it works as advertised - what is it that makes this a vaccine? To me it sounds like a cure or treatment.
The creators call it an inverse vaccine. A vaccine causes the immune system to recognize a compound to attack. This treatment causes the immune system to ignore a compound it had previously recognized. So they are specifically saying it’s not a vaccine (and OP is misrepresenting them), even though that word is in the phrase, something roughly like antivenom is not a venom.
Thanks for the additional clarification!
It is not a cure for the reasons others in this thread have stated. It doesn’t repair damage already done, it only prevents the disease from advancing. That’s still a huge deal, though.
But when it comes to type 1 diabetes the cause is the body destroying beta cells in the pancreas and everything else is a symptom of that. If you can make the body “forget” killing beta cells (like the article states the anti-vaccine would, or rather teach the body to not kill) then it would make sense for the body to recover and repair the damage done.
Wouldn’t it then be a cure?
@be_excellent_to_each_other @m3t00
Vaccines have evolved from prevention/mitigation to now include treatment, and ideally cures.So skimming through the link, it’s a vaccine because it’s still triggering a specific body response to fight the illness as opposed to directly attacking the illness itself? Is that a reasonable layman’s summary of why it’s called a vaccine?
(Old x’er here, Vaccines have been preventative for as long as I’ve ever known, that’s the reason for the question.)
The article says the immune system has a mechanism for teaching it not to attack every time there is a damaged cell via a process in the liver. They are saying they can take a protein, say myelin, and attach it to a sugar called pGal, and it will get ported to the liver where it will also get “trained” to not attack myelin. Then the immune system shouldn’t attack nerve fibers as in MS.
So I guess it qualifies as a vaccine as it is involved in training the immune system though in this case to NOT attack something.
@be_excellent_to_each_other @m3t00
I an X that had the exact same thoughts lol. I’m no expert, but old vaccines often contained some of the virus live or deactivated, whereas mRNA are created and not of biological origin. So more about the front end than the back end.
This sounds quite exciting and it doesn’t smell like bullshit.
Probably extremely affordable at 3 million a pop for 5 shots.
Easy hack. Get a bunch of more affordable health care services during the year until you reach your out-of-pocket max, then go in and get your 3 million worth of shots all on the insurance company’s dime with zero extra cost to you.
Your claim was denied, due to the insurance provider classifying this treatment as elective or cosmetic, not life saving.
Ah, I see you’ve interacted with the American “health insurance” extortion racket.
Or do this one first to max out your out-of-pocket with the one copay, everything else is “free” all year.
“” because you’re still paying premiums
Article from September. First I’m hearing of it…
In my understanding this could reverse the autoimmune reaction to Type 1 Diabetes not regrow the already killed β-cells.
That’s the way it reads, yes.
It would, if effective in human use, stop new damage, but not reverse existing damage.
I was wondering about that, curing Type 1 Diabetes would be a HELL of a breakthrough.
Curing it would lead to massive losses of a specific industry.
Oh fuck yes! I hope this works so badly (living the nightmare with crohns)
One of us…
Hi there! Looks like you linked to a Lemmy community using a URL instead of its name, which doesn’t work well for people on different instances. Try fixing it like this: !crohnsandcolitis@lemmy.world
Thanks, subscribed :)
I wonder if it also applies to ulcerative colitis…
Same here friend. The disease is rough and hits everyone differently. Hope you’re doing alright with things tho :)
I would give anything to be rid of this disease. I haven’t slept a full night since 1996. And the pain… And it always seems like nobody understands. ‘Oh him? He just poops a lot, ignore the doom and gloom.’
@Bo7a @CleoTheWizard
Me too 🎯
I wonder if a similar technique could be used to reduce organ transplant rejection.
Same but allergies.
Ehhh, maybe? If I’m reading the article right (and I haven’t yet gone digging past the article to the source itself because that takes more time than I currently have), it’s targeting t cells only. Rejection involves more than just t cells though.
It might be at least partially effective, I’m not trained in the field to be able to predict that much, just basing what I’m saying off of past reading and general information.
I’m not confident in this, though. It’s pretty damn far beyond the level of actual training I’ve had. I can say confidently that the basic techniques they’re talking about should be applicable to more than just autoimmune disorders, just not the degree of efficacy.
There’s just so many more cells involved in something like hyperacute and acute rejection that it’s likely to be something that would have to be more complicated than the already complicated technique they’re working on.
I would say that, if this proves to work in actual humans safely and effectively, that the immune related cancers would be the more probable beneficiaries of the method.
See, most of the autoimmune stuff is a “false positive” the body at some point got fooled by some kind of external agent, that happened to match some part of the body. So, if you wipe out the “memory” of that false positive, the body stops attacking itself.
The cancers that are immune related should respond in a similar way. You’d still have the malignant cells, but it should stop new ones from going crazy, and the usual methods of killing off the existing malignant cells should effectively “cure” the person with drastically reduced chances of relapse.
But with transplants, there’s no false positive. There actually are foreign cells in the body, being constantly exposed to immune cells. There’s also usually more than one kind of cell, so the method they’re using probably would need multiple efforts to work at all, and would likely need to be administered regularly. I’m fairly confident that the method could reduce severity of rejection, but that’s still only fairly lol. But, (disclaimer again), the method should work in either a single or small number of treatments for autoimmune diseases.
I hope like hell this gets into human trials fast. I have a personal stake in it (hence all the reading lol) and what this thing can’t do is undo the damage already done. The person being treated is still going to have whatever degree of disability the disease already caused, so the sooner people can start the treatment, the better off they are.
Most of the diseases explicitly listed as targets for this treatment are fucking brutal. Just one year with MS, as an example, can take someone from healthy and active to being half blind, or unable to walk unaided, or any number of other issues. MS already takes time to diagnose, so pretty much everyone that has it has some degree of disability by the time they start existing treatments. And the existing treatments, as incredible as they are, don’t fully prevent new damage occurring. Nor do all of them work at full efficacy for everyone. You can end up having to try multiple treatments to find the right one for your immune system.
So, most MS patients have a serious amount of time before their disease even gets slowed. My wife, from diagnosis to first partially effective treatment, went almost a year, and lost so damn much from that time plus the effects from before diagnosis. You’re talking someone that was modeling and a jogger being unable to walk down a hallway until over a year of physical therapy, and still can’t handle long walks.
And she didn’t even lose as much as some people do. She also deals with what’s called relapsing/remitting MS (RRMS) which takes breaks between attacks. People with primary progressive MS (PPMS) can lose function faster and more severely. It’s a fucking terrifying disease.
This is starting to go very long and tangential, so I’ll stop after this bit.
I hope like hell it will work for not only the listed diseases, but rejection too. Gods, the lives it could make better if it can do all of that would change the world, along with the individual lives. It would be the scientific equivalent of a miracle cure.
Awesome, I have an autoimmune desease that can possibly paralyse me in future. I hope progress can continue 🙏
Sounds pretty advanced. I bet they won’t be able to activate the mind control chips until 6G cell services launch.
I was under the impression that we were 5G access points with the covid vaccine?
Was I lied to? I thought I was doing a service to the fellow terminally online.
That’s a bold claim there, dennis
Not only that, it is a repost from three months ago. Not that OP would be expected to know, but it does take off a few “groundbreaking” points.
I mean, it’s making it to human trials so seems a lot more real than most of these “kills cancer cells in a petri dish” sort of things.
What I mean is the actual article linked to is already months old. Also, that’s great, but it’s not out of the woods yet.
I remember seeing something on reddit about this earlier this year iirc. Definitely exciting and I certainly hope there is credence to this. Would love to see auto immune disorders go by the wayside in the next couple decades. Once they fix all the real bad ones I hope they make one for vitiligo, I’m tired of 70 spf sunblock and weird looking tans.
What about Hashimoto’s thyroiditis and Graves’ disease?
This looks promising, way more promising than any other cure for MS I’ve read about
Allergies also?
That is a different kind of immune response. It is not autoimmune, it is hyper responsive.
Yeah, but both are “the immune system attacking something it shouldn’t”, so I wonder if the same mechanism can desensitize it to allergens.
The article mentioned trails for celiac which although it says is autoimmune, at least involves a foreign substanceThe article explains it as tagging your own cells in your body with a marker that makes the immune system ignore them. Doesn’t seem like a foreign body encountered sporadically would work. Allergies and autoimmune (like CL IV celiac) are different classifications of hypersensitivity with different mediating mechanisms. https://en.wikipedia.org/wiki/Hypersensitivity
Is there a fundamental difference between the two? The way I understand it, autoimmune disorders are often basically an allergy to yourself
